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MAD2 Mouse, Unlabeled, Clone: 48, BD

Product Code. 15865579
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Quantity:
150 μg
50 μg
Unit Size:
1 set
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15865579 50 μg 1 set
15875579 150 μg 1 set
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Product Code. 15865579 Supplier BD Biosciences Supplier No. 610678

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Description

Mouse Monoclonal Antibody

Progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. These events are of utmost importance at the checkpoints, or transition points, of the cell cycle. MAD2 (Mitotic Arrest Deficient) is the human homolog of a yeast and Xenopus protein that is essential for spindle assembly during mitosis. The human hsMAD2 gene encodes a protein of 205 amino acids with a predicted molecular weight of 23.5 kDa. Binding of affinity purified polyclonal antibodies to the MAD2 protein prevents mitosis of HeLa cells. This indicates that, like its invertebrate relatives, MAD2 is necessary for mitosis. Furthermore, MAD2 is localized at the kinetochore of condensed chromosomes during mitosis and cells defective in the mitotic checkpoint have reduced levels of MAD2.

TRUSTED_SUSTAINABILITY

Specifications

Antigen MAD2
Applications Western Blot
Classification Monoclonal
Clone 48
Concentration 250μg/mL
Conjugate Unconjugated
Description Mitotic Arrest Deficient-2
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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For Research Use Only.

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