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Description
The TC30-28E3 antibody specifically binds to the β subunit of the mouse Interleukin-18 Receptor complex (IL-18Rβ). The mouse IL-18R complex is expressed by T cells stimulated with IL-12 alone or cultured with antigen and IL-12 to induce Th1 cells. IL-18R is constitutively expressed by NK cells. Resting mouse T cells and Th2 cells do not express detectable levels of IL-18R. The mouse IL-18R complex consists of the IL-18α chain, also known as IL-1 Receptor related protein 1 (IL-1Rrp1 or IL-R5) and the IL-18Rβ chain also known as IL-1R accessory protein-like (IL-1RAcPL or IL-R7). The cell surface IL-18Rα chain binds IL-18 with low affinity. However its interaction with the IL-18Rβ chain confers high affinity binding for the ligand. The IL-18Rβ chain is not involved in ligand binding but is responsible for the transduction of biological signals. The immunogen used to generate the TC30-28E3 hybridoma was sIL-1R7 fusion protein.
Host Species: Rat
Clone: TC30-28E3
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse sIL-1R7 fusion protein
Neutralization
Specifications
| IL-18 Receptor β | |
| Monoclonal | |
| 1.0mg/mL | |
| IL-1RAcPL, IL-R7 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
| Neutralization | |
| TC30-28E3 | |
| Unconjugated | |
| No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay. | |
| Mouse sIL-1R7 fusion protein | |
| 0.5 mg | |
| Immunology | |
| Mouse | |
| IgG2a λ |
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