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Description
Reacts with the F11 receptor (also known as JAM-1), an integral membrane protein duplex of 32-35kDa expressed on platelets, leukocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. The F11R is homologous with the murine protein called Junctional Adhesion Molecule (JAM), a member of the immunoglobulin superfamily. Monoclonal antibody (mAb) F11 is a stimulatory antibody, namely, the binding of F11mAb to F11R induces morphological changes, granular secretion, and aggregation in human platelets that are
mediated by two pathways. Antibody-induced platelet aggregation and granule secretion are dependent on both molecules of FcγRII and GPIIb/IIIa integrin, and that may play a role in some thrombocytopenias. F11R-mediated platelet adhesion and aggregation are not dependent on FcγRII or GPIIb/IIIa and that may play a role in normal platelet physiological processes.
Host Species: Mouse
Clone: M.Ab.F11
Isotype: IgG1 κ
Species Reactivity: Human
Flow Cytometry
Specifications
| F11 Receptor | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| M.AB.F11 | |
| JAM-1; Platelet F11 receptor; F11R; JAM-A; PAM-1 | |
| Mouse | |
| 100 Tests | |
| Cell Biology | |
| Human | |
| IgG1 κ |
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Product Title
For Research Use Only.
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