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CUL-3 Mouse, Unlabeled, Clone: 3, BD

Product Code. 15856039
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Quantity:
50 μg
Unit Size:
1 set
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15856039 50 μg 1 set
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Product Code. 15856039 Supplier BD Biosciences Supplier No. 611848

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Description

Mouse Monoclonal Antibody

The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. Cul-3 is widely expressed in normal cells and tissues, and shows increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination, while deletion of Cul-3 in mice leads to increased cyclin E accumulation and abnormal regulation of S-phase. Thus, the Cul
family of proteins may have roles in cell cycle regulation and tumoriogenesis.

Host Species: Mouse
Clone: 3
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Human CUL-3 aa. 565-684

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CUL-3
Applications Western Blot
Classification Monoclonal
Clone 3
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human CUL-3 aa. 565-684
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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