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CtBP2 (C-Terminal Binding Protein-2) Mouse, Unlabeled, Clone: 16, BD

Product Code. 15886079
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Quantity:
50 μg
Unit Size:
1 set
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15886079 50 μg 1 set
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Product Code. 15886079 Supplier BD Biosciences Supplier No. 612044

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Description

Mouse Monoclonal Antibody

Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a corepressor can bind. C-terminal binding proteins (CtBP1 and CtBP2) are a class of corepressors that interact with a subset of transcription factors through a PLDLSL sequence motif. CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in δEF1. CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important corepressors for a variety of transcriptional factors.

Host Species: Mouse
Clone: 16
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse CtBP2 aa. 361-445

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CtBP2 (C-Terminal Binding Protein-2)
Applications Western Blot
Classification Monoclonal
Clone 16
Concentration 250μg/mL
Conjugate Unconjugated
Description C-Terminal Binding Protein-2
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse CtBP2 aa. 361-445
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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