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Description
Anti-CD4 antibody
The product is subject to the following: Abcam Restricted Use Statement
.The product is subject to the following: Abcam Restricted Use Statement
Specifications
Specifications
| Antigen | CD4 |
| Applications | Immunohistochemistry (FFPE) |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Formulation | pH: 7.6, Preservative: 0.1% Sodium azide, Constituents: PBS, 1% BSA |
| Gene | CD4 |
| Gene Accession No. | P01730 |
| Host Species | Rabbit |
| Immunogen | CD4 |
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Product Title
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