β-Catenin Mouse, Alexa Fluor 488, Clone: 14/Beta-Catenin, BD

The 14/Beta-Catenin monoclonal antibody specifically binds to Beta-Catenin ( β -Catenin). β -Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α - and β -Catenins have been cloned, very little is known about their biochemical roles. However a link between β -Catenin and colon cancer has been described. β -Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.