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β-Arrestin Mouse, Unlabeled, Clone: 10, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 610550
Additional Details : Weight : 0.01000kg
Description
β-Arrestins were discovered due to their ability to modulate interactions between the phosphorylated β2-Adrenergic receptors and G proteins. This modulation results in diminished β2-Adrenergic receptor function, also known as desensitization. Because arrestins are found at the synaptic terminals, they may provide a termination mechanism that allows the neurons to regain their original polarization and respond to a new neurotransmitter stimulus. The C-terminal region of arrestins is involved in selecting the phosphorylated and activated adrenergic receptors. The β-Arrestin1 gene encodes a protein of 418 amino acids with an approximate molecular weight of 55kDa. β-Arrestin1 protein is highly homologous to the 45kDa β-Arrestin2. Both proteins are widely expressed, but are especially abundant in the central nervous system.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
| β-Arrestin | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Rat β-Arrestin1 aa. 262-409 | |
| 50 μg | |
| Cell Biology | |
| Human, Mouse, Rat | |
| IgG1 |
| Western Blot | |
| 10 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.