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  6. ACVR1C Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

ACVR1C Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16870414 Shop All Proteintech Products
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16870414 20 μL 20µL
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Product Code. 16870414 Supplier Proteintech Supplier No. 126101AP20UL

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Description

Rabbit Polyclonal Antibody

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.

Specifications

Antigen ACVR1C
Applications Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene ACVR1C
Gene Accession No. P70539, Q8K348, Q8NER5
Gene Alias activin A receptor, type IC, Activin receptor like kinase 7, Activin receptor type 1C, Activin receptor type IC, ACTR IC, ACVR1C, ACVRLK7, ALK 7, ALK7
Gene Symbols ACVR1C
Host Species Rabbit
Immunogen ACVR1C Fusion Protein Ag3162
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 130399, 245921, 269275
Target Species Human, Rat, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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