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STEMCELL Technologies Zebularine

Product Code. 17160142
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10 mg
Unit Size:
10mg
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17160142 10 mg 10mg
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Product Code. 17160142 Supplier STEMCELL Technologies Supplier No. 72902

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Description

Epigenetic modifier; Inhibits DNA methyltransferases (DNMT)

  • Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs; Zhou et al.)
  • Induces cardiomyocyte differentiation from rat bone marrow mesenchymal stem cells (MSCs; Naeem et al.)
  • Reduces proliferation of the cancer cell lines TK6, Jurkat, KG-1, and HCT116 (Stresemann et al.)
  • Inhibits cell proliferation in T24 bladder carcinoma cells (Ben-Kasus et al.)
  • In combination with the histone deacetylase inhibitor SAHA, reduces cell proliferation and increases apoptosis in pancreatic cancer cell lines (Neureiter et al.)
  • Inhibits cell proliferation and induces apoptosis in human acute myeloid leukemia cells in vitro (Scott et al.)
  • Increases the proportion of cells with cancer stem cell properties in subpopulations of human cancer cells and liver cancer cell lines (Marquardt et al.)

Specifications

CAS 3690-10-6
Synonym NSC 309132
Quantity 10 mg
Molecular Formula C9H12N2O5
Purity ≥98%
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