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Tocris Bioscience™ xStAx-VHLL

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Quantity:
100 μg
Unit Size:
100µg
Beskrivning
xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC™). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
Specifikationer
Specifikationer
| Purity | 95% |
| Content And Storage | Store at -20°C |
| Quantity | 100 μg |
| Target Entry | Active Degraders |
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