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R&D Systems™ XAV 939

Product Code. 18065872
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Product Code. 18065872 Supplier R&D Systems™ Supplier No. 3748/10
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Description

A Tocris product, part of R&D Systems. Potent tankyrase inhibitor

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols.

XAV 939 synthesized to cGMP guidelines also available.

For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 284028-89-3
Molecular Formula C14H11F3N2OS

Specifications

Quantity 10 mg
Product Line Tocris
Formula Weight 312.31
Purity >98%
Molecular Weight (g/mol) 312.31
Chemical Name or Material XAV 939
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