missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. R&D Systems™ Wnt-C59

R&D Systems™ Wnt-C59

Product Code. 18702459
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity Unit Size
18702459 10 mg 10mg
18735708 50 mg 50mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 18702459 Supplier R&D Systems™ Supplier No. 5148/10
  • ONLINE EXCLUSIVE PRICE
    408.00€
    385.35€ / 10mg
    Save 22.65€
    5% Off
 Restricted Item
In Stock
Add to basket
Edge
Add to basket

missing translation for 'validMainframeMsg'

This item is not returnable. View return policy

Description

A Tocris product, part of R&D Systems. Highly potent PORCN inhibitor

Wnt-C59 is a highly potent inhibitor of MBOAT (membrane-bound O-acyltranferase) family member Porcupine (PORCN) (IC50 = 74 pM) that mediates WNT palmitoylation and secretion. Wnt-C59 potently inhibits the processing of both canonical (1, 2, 3a, 6, 7b, 8a, 9a, 9b, 10) and non-canonical (4, 5a, 11, 16) Wnt subtypes. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Wnt-C59 treated tumors show a decrease in β-catenincatenin, CyclinD1 and c-Myc. Wnt-C59 induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Wnt-C59 efficiently induces neural differentiation of CTIP2+/COUP-TF1- cells from PSCs in culture. When grafted into the cortex of adult mice, develop abundant axonal fiber extension toward the spinal cord. Cell permeable and orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 10 mg
Product Line Tocris
Product Type Wnt-C59
Purity >99%
Molecular Weight (g/mol) 379.45
Inhibitors Wnt-C59

For Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.