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  5. Tocris Bioscience™ VU 0424465

Tocris Bioscience™ VU 0424465
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Product Code. 18766126
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18766126

Brand: Tocris Bioscience™ 6895/10

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This item is not returnable. View return policy

Description

Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

VU 0424465 is a potent mGlu5 positive allosteric modulator (EC50 = 1.5 nM) and agonist (EC50 = 171 nM; maximum effect is 65% that of glutamate). Binds allosteric site with high affinity (Ki = 11.8 nM). Increases maximum response to glutamate by 30%. Exhibits bias towards signaling via IP1 and ERK1/2 over iCa2+ in HEK293 and neuronal cells, and activates Gs in HEK 293 cells. Induces epileptiform activity in CA3 hippocampal neurons in vitro and convulsions in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
CAS 1428630-85-6
Quantity 10 mg
Molecular Formula C19H19FN2O2
Purity 98%
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