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Voriconazole, 98%, Thermo Scientific Chemicals

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Quantity:
1 g
Conditionnement:
1g
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Code produit. 15442252

Marque: Thermo Scientific Acros 458670010

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Description

Voriconazole, CAS # 137234-62-9, is an antifungalagent that acts by inhibition of sterol biosynthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Voriconazole is an antifungal compound that has activity against a wide variety of fungal species including Aspergillus and Candida
  • Voriconazole blocks sterol biosynthesis in Candida species through inhibition of CYP450-dependent 14-alpha sterol demethylase
  • It depletes the presence of ergosterol in the fungal cell membrane, which can lead to death or growth inhibition, depending on the organism

Applications

  • Voriconazole may be used in laboratory studies of drug safety, pharmacokinetics, and mechanism of action
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Spécification

Type Voriconazole
CAS 137234-62-9
Melting Point 128.0°C to 134.0°C
Infrared Spectrum Authentic
Loss on Drying 0.5% max.
Quantity 1 g
Molecular Formula C16H14F3N5O
Solubility Information Solubility in water: insoluble in water. Other solubilities: soluble in methanol,acetonitrile
InChI Key BCEHBSKCWLPMDN-MGPLVRAMSA-N
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
IUPAC Name (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
Molecular Weight (g/mol) 349.317
PubChem CID 71616
ChEBI CHEBI:10023
Formula Weight 349.31
Percent Purity 98%
Chemical Name or Material Voriconazole
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Sécurité et traitement

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Identifiant produit
  • Voriconazole
 Mention d'avertissement
  • Danger
 Catégorie de danger
  • Acute toxicity Category 3
  • LONG-TERM AQUATIC HAZARD Chronic 3
  • Carcinogenicity Category 2
  • Reproductive toxicity Category 1A
  • Specific target organ toxicity after repeated exposure Category 2
 Mention de danger
  • H360-May damage fertility or the unborn child.
  • H351-Suspected of causing cancer.
  • H373-May cause damage to organs.
  • H412-Harmful to aquatic life with long lasting effects.
  • H301-Toxic if swallowed.
 Conseils de prudence
  • P201-Obtain special instructions before use.
  • P264-Wash thoroughly after handling.
  • P273-Avoid release to the environment.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /

RUO – Research Use Only

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