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Thermo Scientific Chemicals Trimethoprim

Product Code. 15455319
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Product Code. 15455319 Supplier Thermo Scientific Chemicals Supplier No. J63053.06
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Description

Trimethoprim, CAS # 738-70-5, is a trimethoxybenzyl-pyrimidine used as an antimicrobial. | CAS: 738-70-5 | C14H18N4O3

An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.Trimethoprim is an antibiotic involved in the treatment of urinary tract infections, middle ear infections and traveler’s diarrhea. It is associated with sulfamethoxazole and interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Furthermore, It is also used to treat and prevent Pneumocystis jiroveci pneumonia.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Trimethoprim is a synthetic pyrimidine analog that binds dihydrofolate-reductase and inhibits the synthesis of folic acid; when paired with sulfamethoxazole, its activity is enhanced
  • Trimethoprim has antibacterial and antiprotozoal properties

Applications

  • Trimethoprim inhibits the conversion of para-aminobenzoic acid (PABA) to folic acid near the end of the synthesis pathway and can be used to study related effects
  • Trimethoprim has been radiolabeled and used to trace routes of infection, and it also has been used experimentally as a fluorescent labeler to quantify dihydrofolate-reductase expression
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 738-70-5
Molecular Formula C14H18N4O3
Synonym 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Specifications

Quantity 5 g
Description White
Content And Storage 2°C to 8°C
Format Powder
For Use With (Application) An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme
Formula Weight 290.32g/mol
Melting Point 199°C to 203°C
Solubility Trimethoprim is soluble in water at 0.4 mg/ml; It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml
Product Type Signal Transduction Reagent
Form Powder
Beilstein 625127
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Safety and Handling

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Product Identifier
  • Trimethoprim
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
 Hazard Statement
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contain: Trimethoprim
SDS

RUO – Research Use Only

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