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  5. STEMCELL Technologies Thiazovivin

STEMCELL Technologies Thiazovivin

Product Code. 17100052
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Quantity:
1 mg
5 mg
25 mg
Unit Size:
1mg
25mg
5mg
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Product Code. 17100052

Brand: STEMCELL Technologies 72254

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Description

RHO/ROCK pathway inhibitor; Inhibits ROCK

  • Thiazovivin is a selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK), a serine/threonine kinase that plays a role in cell polarity, contraction, and actin cytoskeleton reorganization (Xu et al.) Thiazovivin is effective at 5-fold-lower concentrations than another common ROCK inhibitor Y-27632 (Catalog #72302; Xu et al.)
  • Promotes survival of human embryonic stem (ES) cells during dissociation by stabilizing E-cadherin and improves cell attachment (Xu et al.)
  • Promotes survival of single human induced pluripotent stem (iPS) cells during transfection for TALEN-mediated genome editing (Sun and Zhao)
  • Increases the efficiency of reprogramming human somatic cells to iPS cells, in combination with PD0325091 and SB431542 (Lin et al.)
  • Increases the efficiency of reprogramming human cord blood mononuclear cells to iPS cells (Hu et al.)

Specifications

CAS 1226056-71-8
Synonym Tzv
Quantity 5 mg
Molecular Formula C15H13N5OS
Purity ≥98%
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