missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ TH 9619 disodium salt

Tocris Bioscience™ TH 9619 disodium salt
GREENER_CHOICE

Product Code. 18014022
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 18014022

Brand: Tocris Bioscience™ 7719/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

MTHFD2 inhibitor

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AmL) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AmL.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate
Quantity 10 mg
Target Dehydrogenase Inhibitors
Molecular Formula C17H16FN7Na2O7
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.