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  5. Tocris Bioscience™ TH 9619 disodium salt

Tocris Bioscience™ TH 9619 disodium salt
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Product Code. 18014022
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50 mg
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18014022 10 mg 10mg
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Product Code. 18014022 Supplier Tocris Bioscience™ Supplier No. 7719/10

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Description

MTHFD2 inhibitor

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AmL) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AmL.
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Specifications

Chemical Name or Material Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate
Quantity 10 mg
Target Dehydrogenase Inhibitors
Molecular Formula C17H16FN7Na2O7
Purity 0.98
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