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STEMCELL Technologies SU9516

Product Code. 17180222
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10 mg
Unit Size:
10mg
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17180222 10 mg 10mg
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Product Code. 17180222 Supplier STEMCELL Technologies Supplier No. 73452

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Description

Cyclin/CDK pathwayiInhibitor; Inhibits CDK1 and CDK2

  • SU9516 is a specific inhibitor of cyclin-dependent kinases (CDKs) including CDK2, CDK1 and, to a lesser extent, CDK4 with IC50 values of 22, 40, and 200 nM, respectively (Lane et al.) It competitively binds in the ATP binding pocket of CDK2 and CDK1 (Moshinsky et al.) It is highly selective and does not inhibit PKC, p38 MAPK, PDGFR or EGFR (IC50 > 10 μM; Lane et al.)
  • Decreases proliferation in human colon carcinoma cell lines RKO and SW480, through inhibition of retinoblastoma protein (Rb) phosphorylation, resulting in increased Rb/E2F, cell-cycle arrest, and subsequent apoptosis (Lane et al.; Yu et al.)
  • Induces mitochondrial injury, caspase activation and subsequent apoptosis through downregulated transcription of the antiapoptotic protein MCL-1 in U937, Jurkat, and HL-60 leukemia or lymphoma cell lines (Gao et al.)
  • Induces apoptosis, alone or in combination with paclitaxel, in the inflammatory breast cancer cell line SUM149PT (Opyrchal et al.)

Specifications

CAS 377090-84-1
Quantity 10 mg
Molecular Formula C13H11N3O2
Purity ≥98%
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