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STAT1 Rabbit anti-Human, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
140.00€ - 399.00€
Specifications
Antigen | STAT1 |
---|---|
Concentration | 0.13 mg/mL |
Applications | Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16866333
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Proteintech
10144-2-AP-20UL |
20 μL |
140.00€
20µL |
Estimated Shipment: 02-07-2024
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16856333
|
Proteintech
10144-2-AP-150UL |
150 μL |
399.00€
150µL |
Estimated Shipment: 02-07-2024
Log in to see stock. |
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Description
This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT1.
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.Specifications
STAT1 | |
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation | |
Unconjugated | |
Rabbit | |
Human, Rat | |
P42224 | |
25124, 6772 | |
STAT1 Fusion Protein Ag0199 | |
Primary | |
-20°C | |
STAT1 |
0.13 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
ISGF 3, STAT1, STAT91 | |
STAT1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |