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Tocris Bioscience™ SJFd

Product Code. 18065632
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5 mg
Unit Size:
5mg
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18065632 5 mg 5mg
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Product Code. 18065632 Supplier Tocris Bioscience™ Supplier No. 7267/5

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Description

Potent and selective p38δ PROTAC™

SJFδ is a potent and selective PROTAC ™ Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,
CAS 2254609-23-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C62H63F2N7O12S
Purity 98%
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