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R&D Systems™ SAH-SOS1A

Product Code. 18788726
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Quantity:
500 μg
Unit Size:
500µg
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Product Code. Quantity Unit Size
18788726 500 μg 500µg
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Product Code. 18788726 Supplier R&D Systems™ Supplier No. 6920/500U
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Estimated Shipment: 13-11-2026
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Description

A Tocris product, part of R&D Systems. KRas/SOS1 interaction inhibitor

SAH-SOS1A is a KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

Sold under license from Dana-Farber Cancer Institute

TRUSTED_SUSTAINABILITY

Specifications

Product Line Tocris
CAS 1652561-87-9
Content And Storage Store at -20°C
Description KRas/SOS1 interaction inhibitor
Formulation C100H159N27O28
Molecular Weight (g/mol) 2187.53
Quantity 500 μg
Sequence RRFFGIXLTNXLKTEEGN (Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-7 and X-11 stapled together with a double bond)
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