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DiscoverX Ready-to-Assay™ GLP-1 Receptor Frozen Cells

Product Code. 17325309
Encompass
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Quantity:
2 Vials of Cells
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17325309

Brand: DiscoverX HTS163LRTA

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This item is not returnable. View return policy

Description

The Ready-to-Assay™ GLP-1 Receptor Frozen Cells measure GLP1R (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.

The Ready-to-Assay™ GLP-1 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. GLP-1) based activation of GLP1R GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress GLP1R alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of GLP1R , the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.

Specifications

Assay Entry GLP-1
For Use With (Application) Frozen Cells
Primary Agonist GLP-1
Quantity 2 Vials of Cells
Target Entry GLP1R
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