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DiscoverX Ready-to-Assay™ CXCR3 Chemokine Receptor Frozen Cells

Product Code. 17364949
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Quantity:
2 Vials of Cells
Unit Size:
2 ampoules
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Product Code. Quantity unitSize
17364949 2 Vials of Cells 2 ampoules
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Product Code. 17364949 Supplier DiscoverX Supplier No. HTS003LRTA

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Description

The Ready-to-Assay™ CXCR3 Chemokine Receptor Frozen Cells measure CXCR3 (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.

The Ready-to-Assay™ CXCR3 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. CXCL11/I-TAC) based activation of CXCR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress CXCR3 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of CXCR3 , the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.

Specifications

Assay Entry CXCR3
For Use With (Application) Frozen Cells
Primary Agonist CXCL11/I-TAC
Quantity 2 Vials of Cells
Target Entry CXCR3
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