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ACROBiosystems Rat PCSK9 Protein, His Tag

Brand:  ACROBiosystems PC9-R52H4-50UG

Additional Details : Weight : 0.00001kg

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Product Code. 15807447

  • 262.28€ / 50µg


Estimated Shipment: 25-10-2021
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Description

Description

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculated
Specifications

Specifications

NP_954862.2
HEK293
Rat
13.9 kDa and 59.3 kDa
50 µg
Gln 31 - Gln 691
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by reduced SDS-PAGE
Rat PCSK9, His Tag (PC9-R52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 691 (Accession # P59996-1).
-20°C
PCSK9
His Tag
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