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  5. Tocris Bioscience™ Raphin 1

Tocris Bioscience™ Raphin 1
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Product Code. p-7161666
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18779936 10 mg 10mg
18797296 50 mg 50mg
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Product Code. 18779936 Supplier Tocris Bioscience™ Supplier No. 6760/10

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Description

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1 (Kd = 33 nM); orally bioavailable and brain penetrant

Raphin 1 is an inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant.
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Specifications

Chemical Name or Material (2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide
CAS 2022961-17-5
Quantity 10 mg
Molecular Formula C8H8Cl2N4
Formula Weight 231.08
Purity 98%
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