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PSC 833, Tocris Bioscience™

Catalog Number 18094372
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Quantity:
1 mg
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Description

Inhibitor of P-gp-mediated MDR

P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).
CAS 121584-18-7
Molecular Formula C63H111N11O12
MDL Number MFCD00907207
Quantity 1 mg
Synonym valspodar, amdray, sdz psc 833, sdz-psc-833, 3'-keto-bmt 1-val 2-cyclosporin a, unii-q7zp55kf3x, amdray tn, valspodar usan/inn, q7zp55kf3x, sdz-psc 833
InChI Key YJDYDFNKCBANTM-QCWCSKBGSA-N
SMILES C\C=C\C[C@@H](C)C(=O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C
IUPAC Name (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,28-nonamethyl-33-[(2R,4E)-2-methylhex-4-enoyl]-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tris(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
Molecular Weight (g/mol) 1214.65
PubChem CID 5281884
ChEBI CHEBI:8985
Formula Weight 1214.62
Percent Purity >98%
Chemical Name or Material PSC 833
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