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Progesterone, 98%, Thermo Scientific Chemicals

Progesterone, CAS # 57-83-0, is a naturally occurring hormone required for maintenance of the uterine endothelium and suppression of estrogens.

38.95€ - 327.00€

Chemical Identifiers

CAS 57-83-0
Molecular Formula C21H30O2
Molecular Weight (g/mol) 314.46
MDL Number MFCD00003658
InChI Key RJKFOVLPORLFTN-LEKSSAKUSA-N
Synonym progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
PubChem CID 5994
ChEBI CHEBI:17026
IUPAC Name (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
SMILES CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
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Thermo Scientific Acros
225650050 		5 g Glass bottle
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Thermo Scientific Acros
225650250 		25 g Glass bottle
124.00€
25g
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Thermo Scientific Acros
225651000 		100 g Glass bottle
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100g
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Description

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation

• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility

Applications

• Progesterone signaling is relevant to the study of breast cancer

Literature References

Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.

Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.

Specifications

Chemical Identifiers

57-83-0
314.46
RJKFOVLPORLFTN-LEKSSAKUSA-N
5994
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
C21H30O2
MFCD00003658
progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
CHEBI:17026
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Specifications

57-83-0
Brown-Yellow to Yellow
Authentic
C21H30O2
15, 7889
+ 190
Solubility in water: insoluble. Other solubilities: soluble in alcohol,acetone,dioxane,conc. h2so4
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
314.46
CHEBI:17026
98%
Progesterone
126°C to 131°C
0.5% max. (500 mg, 105°C, 2 hrs)
97.5% min. (HPLC)
MFCD00003658
+190° (20°C c=1,ethanol)
progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
RJKFOVLPORLFTN-LEKSSAKUSA-N
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
5994
314.46
Crystalline Powder, Crystals or Chunks
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Safety and Handling

Safety and Handling

GHS H Statement:
Suspected of causing cancer.

GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

GHS Signal Word: Warning

missing translation for 'einecsNumber' : 200-350-6

Product Identifier
  • Progesterone

Signal Word
  • Warning

Hazard Category
  • Carcinogenicity Category 2

Hazard Statement
  • H351-Suspected of causing cancer.

Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.

SDS
Documents

Documents

Product Certifications

RUO – Research Use Only

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