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PLK4 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA529373
Additional Details : Weight : 0.01000kg
Description
Recommended positive controls: PLK4-transfected 293T. Predicted reactivity: Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.Specifications
PLK4 | |
Polyclonal | |
Unconjugated | |
PLK4 | |
1700028H20; AI385771; MCCRP2; PLK4; PLK-4; polo like kinase 4; polo-like kinase 4; SAK; serine/threonine kinase 18; serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak; Snk akin kinase; Stk18 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
10733 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Western Blot | |
0.19 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 | |
O00444 | |
PLK4 | |
Recombinant fragment corresponding to a region within amino acids 614 and 871 of Human PLK4 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |