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Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5-110155
This item is not returnable.
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Description
Sequence of this protein is as follows: SSMS
Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.
Specifications
| Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) | |
| Polyclonal | |
| Unconjugated | |
| SMAD3 | |
| 7120426M23Rik; AU022421; hMAD-2; hSMAD2; HSPC193; HsT17436; JV15-2; JV18; JV18-1; LDS1C; LDS3; MAD homolog 2; MAD homolog 3; Mad protein homolog; mad3; MADH2; MADH3; Madr2; Mad-related protein 2; mMad2; Mothers against decapentaplegic homolog 2; Mothers against decapentaplegic homolog 3; pSMAD2; SMAD; SMAD 2; SMAD 3; SMAD family member 2; SMAD family member 3; Smad2; Smad-2; Smad3 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 4087, 4088 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry, Western Blot | |
| 0.58 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P84022, Q15796 | |
| SMAD2, SMAD3 | |
| A synthetic phosphorylated peptide around S465 & S467 of human Smad2 (NP_005892.1). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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