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DiscoverX PathHunter™ U2OS TrkB-P75 Functional Assay

Product Code. 17323349
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17323349 2 Vials 2 ampoules
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Product Code. 17323349 Supplier DiscoverX Supplier No. 930530C3

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Description

The PathHunter™ U2OS TrkB-P75 Functional Assay measures TrkB-P75 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS TrkB-P75 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkB and P75 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged TrkB and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, P75 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Activation
Cell Line U2OS
Format 2 vials
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human BDNF
Quantity 2 Vials
Target Entry TrkB-P75
Accession Number NM_006180
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