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DiscoverX PathHunter™ U2OS TGFBR1/TGFBR2/ENG Dimerization Cell Line

Product Code. 17354399
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17354399 2 Vials 2 ampoules
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Product Code. 17354399 Supplier DiscoverX Supplier No. 931122C3

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Description

The PathHunter™ U2OS TGFBR1/TGFBR2/ENG Dimerization Cell Line measures ligand-induced dimerization of TGFBR1/TGFBR2/ENG . This cell line ships as two vials of cryopreserved cells.

The PathHunter™ TGFBR1/TGFBR2/ENG Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TGF-β1) induced dimerization of TGFBR1/TGFBR2/ENG receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1 target protein fused to PK alongside TGFBR2 target protein fused to EA and untagged ENG. Upon ligand-induced dimerization of TGFBR1/TGFBR2/ENG , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Dimerization
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist TGF-β1
Quantity 2 Vials
Target Entry TGFBR1/TGFBR2/ENG
Accession Number NM_004612
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