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DiscoverX PathHunter™ U2OS PRβ Protein Interaction Cell Line

Product Code. 17323899
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Quantity:
2 Vials
Conditionnement:
2 ampoules
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Code produit. Quantity unitSize
17323899 2 Vials 2 ampoules
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Code produit. 17323899 Fournisseur DiscoverX Code fournisseur 930851C3

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Description

The PathHunter™ U2OS PRβ Protein Interaction Cell Line measures activated PRβ nuclear hormone receptor interaction with SRCPs. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ PRβ Protein Interaction cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting NHR activation and recruitment of cofactors. This cell line enables assessment of ligand (e.g. testosterone, norgestrel) based NHR activation via detection of SRCP (steroid receptor co-activator peptide) recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged PRβ NHR and EA-tagged steroid receptor co-activator peptide (SRCP). Upon activation of PRβ, induced interaction with SRCP leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Spécification

Assay Entry Protein Interaction
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist D(-)-Norgestrel
Quantity 2 Vials
Target Entry PRβ
Accession Number NM_000926
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