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DiscoverX PathHunter™ U2OS p53 Nuclear Translocation Cell Line

Product Code. 17373769
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17373769 2 Vials 2 ampoules
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Product Code. 17373769 Supplier DiscoverX Supplier No. 930757C3

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Description

The PathHunter™ U2OS p53 Nuclear Translocation Cell Line measures p53 DNA damage pathway activation via nuclear translocation of p53. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS p53 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the p53 DNA damage pathway. This cell line enables assessment of ligand (e.g. camptothecin) based pathway activation via detection of resulting p53 nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged p53 and nuclear localized EA alongside untagged Keap1. Upon pathway activation, induced nuclear translocation of p53 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry p53 Nuclear Translocation
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Camptothecin
Quantity 2 Vials
Target Entry p53
Accession Number NM_000546.2
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