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DiscoverX PathHunter™ U2OS mHTR2C β-Arrestin Cell Line

Product Code. 17303819
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17303819

Brand: DiscoverX 930790C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS mHTR2C β-Arrestin Cell Line measures mHTR2C (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Mouse protein.

The PathHunter™ mHTR2C β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of mHTR2C GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged mHTR2C and EA-tagged β-Arrestin 2. Activation of mHTR2C stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the mouse version of this protein.

Specifications

Assay Entry β-Arrestin Recruitment
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Serotonin/5-HT
Quantity 2 Vials
Target Entry mHTR2C
Accession Number NM_008312
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