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DiscoverX PathHunter™ U2OS MC5R β-Arrestin Cell Line

Product Code. 17392779
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17392779

Brand: DiscoverX 930231C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS MC5R β-Arrestin Cell Line measures MC5R (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ MC5R β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. α-MSH) based activation of MC5R GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged MC5R and EA-tagged β-Arrestin 2. Activation of MC5R stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin recruitment
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Melanotan II
Quantity 2 Vials
Target Entry MC5R
Accession Number NM_005913
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