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DiscoverX PathHunter™ U2OS IL1RL1/IL1RAP Dimerization Cell Line

Product Code. 17394329
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17394329 2 Vials 2 ampoules
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Product Code. 17394329 Supplier DiscoverX Supplier No. 931067C3

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Description

The PathHunter™ U2OS IL1RL1/IL1RAP Dimerization Cell Line measures ligand-induced dimerization of IL1RL1/IL1RAP . This cell line ships as two vials of cryopreserved cells.

The PathHunter™ IL1RL1/IL1RAP Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-33) induced dimerization of IL1RL1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RL1 target protein fused to PK alongside IL1RAP target protein fused to EA. Upon ligand-induced dimerization of IL1RL1/IL1RAP, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Dimerization
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist IL-33
Quantity 2 Vials
Target Entry IL1RL1/IL1RAP
Accession Number NM_016232.4
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