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DiscoverX PathHunter™ U2OS HTR1B β-Arrestin Cell Line

Product Code. 17333679
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17333679 2 Vials 2 ampoules
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Product Code. 17333679 Supplier DiscoverX Supplier No. 930697C3

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Description

The PathHunter™ U2OS HTR1B β-Arrestin Cell Line measures HTR1B (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ HTR1B β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of HTR1B GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged HTR1B and EA-tagged β-Arrestin 2. Activation of HTR1B stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin recruitment
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Serotonin/5-HT
Quantity 2 Vials
Target Entry HTR1B
Accession Number NM_000863
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