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DiscoverX PathHunter™ U2OS FGFR4-α-Klotho Functional Assay

Product Code. 17384389
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Quantity:
2 Vials
Unit Size:
2 ampoules
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Product Code. Quantity unitSize
17384389 2 Vials 2 ampoules
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Product Code. 17384389 Supplier DiscoverX Supplier No. 931115C3

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Description

The PathHunter™ U2OS FGFR4-α-Klotho Functional Assay measures FGFR4-α-Klotho receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS FGFR4-α-Klotho Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated FGFR4 and α-Klotho dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged FGFR4 and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, α-Klotho Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Phosphorylation
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist FGF-23
Quantity 2 Vials
Target Entry FGFR4-α-Klotho
Accession Number NM_002011
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