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DiscoverX PathHunter™ U2OS FcγRIIa Clustering Cell Line

Product Code. 17314419
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Quantity:
2 Vials
Unit Size:
2 ampoules
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Product Code. Quantity unitSize
17314419 2 Vials 2 ampoules
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Product Code. 17314419 Supplier DiscoverX Supplier No. 931140C3

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Description

The PathHunter™ U2OS FcγRIIa Clustering Cell Line is used to determine cross-linking based potency increases of agonist antibodies. This cell line ships as two vials of cryopreserved cells.

The Path Hunter FcγRIIa clustering cell line is a stable, engineered cell line designed to increase signal produced from a Checkpoint Cell Line via antibody-mediated crosslinking of the receptors. This product is a companion product used to determine cross-linking based increases in potency of agonist antibodies. The cell line included overexpresses FcγRIIa Fcg receptor. When co-cultured with a Checkpoint Cell Line in the presence of agonist antibody, the Fcg receptor binds to the antibody, inducing receptor clustering. The induced receptor clustering leads to increased activation and downstreamsignaling, leading to increased EFC signal production. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Clustering
Cell Line U2OS
For Use With (Application) Cell Lines
Quantity 2 Vials
Target Entry FcγRIIa
Accession Number NM_001136219.1
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