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DiscoverX PathHunter™ U2OS CCR10 β-Arrestin Cell Line

Product Code. 17322889
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17322889 2 Vials 2 ampoules
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Product Code. 17322889 Supplier DiscoverX Supplier No. 930276C3

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Description

The PathHunter™ U2OS CCR10 β-Arrestin Cell Line measures CCR10 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ CCR10 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g.CCL27/CTACK ) based activation of CCR10 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged CCR10 and EA-tagged β-Arrestin 2. Activation of CCR10 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin recruitment
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human CTACK (CCL27)
Quantity 2 Vials
Target Entry CCR10
Accession Number AY429103
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