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DiscoverX PathHunter™ TACR3 Activated GPCR Internalization U2OS Cell Line

Product Code. 17343639
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17343639

Brand: DiscoverX 930678C3

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This item is not returnable. View return policy

Description

The PathHunter™ TACR3 Activated GPCR Internalization U2OS Cell Line measures TACR3 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ TACR3 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. neurokinins, senkitide, substance P) based internalization of TACR3 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged TACR3. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting TACR3-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Internalization
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Senktide, [Succinyl-Asp6, NMephe8]-Substance P (6-11)
Quantity 2 Vials
Target Entry TACR3
Accession Number NM_001059
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