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DiscoverX PathHunter™ NCI-H460 CDC25A Degradation Cell Line

Product Code. 17343799
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17343799 2 Vials 2 ampoules
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Product Code. 17343799 Supplier DiscoverX Supplier No. 930776C12

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Description

The PathHunter™ NCI-H460 CDC25A Degradation Cell Line measures pathway activation-induced degradation of CDC25A target protein. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ NCI-H460 CDC25A Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the cell cycle checkpoint pathway. This cell line enables detection of levels of CDC25a, allowing for assessment of CHK-1-activation-induced CDC25a degradation. This product uses EFC technology. The cell line included overexpresses CDC25a target protein fused to PL. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of CDC25a EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry CDC25A Degradation
Cell Line NCI-H460
For Use With (Application) Cell Lines
Primary Agonist Doxorubicin Hydrochloride
Quantity 2 Vials
Target Entry CDC25A
Accession Number NM_001789.2
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