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DiscoverX PathHunter™ FPR1 Total GPCR Internalization U2OS Cell Line

Product Code. 17353929
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17353929

Brand: DiscoverX 930873C3

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This item is not returnable. View return policy

Description

The PathHunter™ FPR1 Total GPCR Internalization U2OS Cell Line measures FPR1 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ FPR1 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. formylpeptides) based internalization of FPR1 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses PK-tagged FPR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the FPR1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Internalization
Cell Line U2OS
Format 2 vials
For Use With (Application) Cell Lines
Primary Agonist WKYMVm-NH2
Quantity 2 Vials
Target Entry FPR1
Accession Number NM_002029
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