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DiscoverX PathHunter™ CHO-K1 RARα Protein Interaction Cell Line

Product Code. 17382989
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17382989

Brand: DiscoverX 930325C2

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This item is not returnable. View return policy

Description

The PathHunter™ CHO-K1 RARα Protein Interaction Cell Line measures activated RARα nuclear hormone receptor interaction with SRCPs. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ RARα Protein Interaction cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting NHR activation and recruitment of cofactors. This cell line enables assessment of ligand (e.g. retinoic acid) based NHR activation via detection of SRCP (steroid receptor co-activator peptide) recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged RARα NHR and EA-tagged steroid receptor co-activator peptide (SRCP). Upon activation of RARα, induced interaction with SRCP leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Protein Interaction
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist 9-cis-Retinoic acid
Quantity 2 Vials
Target Entry RARα
Accession Number NM_000964
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