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DiscoverX PathHunter™ CHO-K1 MR Protein Interaction Cell Line

Product Code. 17383769
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17383769 2 Vials 2 ampoules
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Product Code. 17383769 Supplier DiscoverX Supplier No. 930758C2

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Description

The PathHunter™ CHO-K1 MR Protein Interaction Cell Line measures MR nuclear hormone receptor activation via nuclear translocation. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ MR Protein Interaction cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting NHR activation and recruitment of cofactors. This cell line enables assessment of ligand (e.g. aldosterone) based NHR activation via detection of SRCP (steroid receptor co-activator peptide) recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged MR NHR and EA-tagged steroid receptor co-activator peptide (SRCP). Upon activation of MR, induced interaction with SRCP leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Activation
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist Aldosterone
Quantity 2 Vials
Target Entry MR
Accession Number NM_000901
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