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DiscoverX PathHunter™ CHO-K1 GPR148 β-Arrestin Orphan GPCR Cell Line

Product Code. 17393039
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17393039 2 Vials 2 ampoules
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Product Code. 17393039 Supplier DiscoverX Supplier No. 930364C2A

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Description

The PathHunter™ CHO-K1 GPR148 β-Arrestin Orphan GPCR Cell Line measures GPR148 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ GPR148 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR148 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged GPR148 and EA-tagged β-Arrestin 2. Activation of GPR148 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Orphan receptor with unknown ligand.

Specifications

Assay Entry β-Arrestin recruitment
Cell Line CHO-K1
For Use With (Application) Cell Lines
Quantity 2 Vials
Target Entry GPR148
Accession Number NM_207364.1
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