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DiscoverX PathHunter™ CHO-K1 GHSR1b β-Arrestin Orphan GPCR Cell Line

Product Code. 17323029
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Quantity:
2 Vials
Unit Size:
2 ampoules
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Product Code. Quantity unitSize
17323029 2 Vials 2 ampoules
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Product Code. 17323029 Supplier DiscoverX Supplier No. 930354C2A

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Description

The PathHunter™ CHO-K1 GHSR1b β-Arrestin Orphan GPCR Cell Line measures GHSR1b (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ GHSR1b cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ghrelin) based activation of GHSR1b GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged GHSR1b and EA-tagged β-Arrestin 2. Activation of GHSR1b stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin recruitment
Cell Line CHO-K1
For Use With (Application) Cell Lines
Quantity 2 Vials
Target Entry GHSR1b
Accession Number NM_004122
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