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  5. Tocris Bioscience™ Olaparib

Tocris Bioscience™ Olaparib
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Product Code. 18719856
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18719856 10 mg 10mg
18799536 50 mg 50mg
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Product Code. 18719856 Supplier Tocris Bioscience™ Supplier No. 7579/10

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Description

Potent PARP inhibitor

Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
CAS 763113-22-0
Quantity 10 mg
Target Poly(ADP-ribose) Polymerase Inhibitors
Molecular Formula C24H23FN4O3
Purity 0.98
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