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STEMCELL Technologies (±)-Nutlin-3

Product Code. 17120272
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
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Product Code. 17120272

Brand: STEMCELL Technologies 73752

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This item is not returnable. View return policy

Description

p53 pathway activator; Inhibits MDM2

  • (±)-Nutlin-3 is a small-imidazoline-based mouse double minute 2 (MDM2) protein antagonist which disrupts MDM2-p53 interaction (IC50 = 0.09 μM; Vassilev et al.) MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability
  • By disrupting this interaction, (±)-Nutlin-3 therefore promotes the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53 (Vassilev et al.), Gu et al.)

Specifications

CAS 548472-68-0
Quantity 1 mg
Molecular Formula C30H30Cl2N4O4
Purity >98%
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